纳米毒理学：毒性生物效应 纳米粒子新评价标准
关键建立新毒理学研究偏离修改传统方法
新兴意义设计高性纳米材料继续研究未更程度利广泛生物医学越越关注出现寻常意想毒性需性更高反应寻常复杂形状障碍细胞造材料具纳米级[114]建立新毒理学研究偏离修改常规方法必少
纳米粒子影响难评估生物学素细胞吸收体行排泄种素控制改变组成形态路线剂量显着影响免疫反应毒副作外预见细胞毒性毒性试验干扰控制足属性影响特定结果
方面纳米特殊焦点问题提供机会阅读讨显著纳米毒理学研究工作方面新方法生物模型实验关注Drezek事目前已提供广泛审查纳米生物分布毒性状态研究[15]作者讨长期体研究必性充分调查毒性免疫反应排泄纳米粒子需时间体外实验中走系统化方法纳米粒子间改进相关属性观察影响解决新兴纳米技术安全标准库克事审查讨
目前体外毒性分析检测性重问题性组建议系列控件
提高实验质量增加纳米技术安全持续利未[16]外李事强调重纳米粒子细胞毒性实验影响素改进实验注意事项需解决问题获数更界定利影响纳米粒子[17]波特事审查讨表征碳纳米毒性互补纳米测量需理化性质毒性[18]作者建议组合高分辨率电子显微镜解技术细胞活力检测网站定位毒性机制稳定细胞碳纳米组织关纳米材料具体类Fubini定讨类纳米粒子高宽重点相关特性导致毒性作[19]作者指出形式组合相似处足建立毒性规模效应形式耐久性组成表面改性必须追究高长宽纳米粒子蔡财提供概述细胞摄取机制行层状双金属氢氧化物毒性体外体注重效果理化性质剂量互动生物相容性生物系统
[20]张BAUMER研究文章中蒙泰罗里维耶尔探讨毒性细胞树突状细胞量子点吸收脱落细胞赖新光源摄取细胞类型细胞分化途径[21]加西亚·贝特出概述序介孔纳米材料应集中高表面积孔体积装载释放力等纳米粒子行[22]stensberg事提供激烈讨
研究运输活动细胞纳米银生命生物体水传统方式结合成立纳米粒子方法表征[23]作者提出基样研究机制调查新银纳米粒子吸收运动建立更模型评估长期体影响研究集中改善生物相容性新型纳米粒子毒性限制提出问题陈周讨战略疏水纳米粒子双亲聚合物限度减少毒性增强纳米粒子稳定性聚合物保护壳[24]李某事谈成功评价生物相容性聚巴胺专注血液中免疫原性组织炎症反应[25]该组发现聚巴胺提供生物相容性纳米涂层材料表面会否表现出定程度毒性 leeand事提供透视纳米粒子作解毒方法物种通身体讨作台二氧化硅纳米化学氧化活性降低毒化合物[做研究[26]
鉴越越关注两新纳米功材料发展健康环境问题关系材料领域研究员负责完整理解纳米材料理化性质开发新标准建立新标准领域识需长时间（10年）然寻求新纳米医学技术会造成延迟
参考书目
特说明文件已强调
撤消修改
1 Amin RM Mohamed MB Ramadan MA Verwanger T Krammer B Rapid and sensitive microplate assay for screening the effect of silver and gold nanoparticles on bacteria Nanomedicin(Lond) 4(6) 637–643 (2009)
n Nanoparticlebased sensing technology
2 Muthu MS Wilson B Multifunctional radionanomedicine a novel nanoplatform for cancer imaging and therapy Nanomedicine (Lond) 5(2) 169–171 (2010)
n Enhanced imaging technology by nanomaterials
3 Bai X Son SJ Zhang SX et al Synthesis of superparamagnetic nanotubes as MRI contrast agents and for cell labeling Nanomedicine (Lond) 3(2) 163–174 (2008)
4 Nie S Understanding and overcoming major barriers in cancer nanomedicine Nanomedicine (Lond) 5(4) 523–528 (2010)
n Discusses technical barriers of cancer nanotechnology
5 Son SJ Bai X Lee SB Inorganic hollow nanoparticles and nanotubes in nanomedicine part 1 Druggene delivery applications Drug Discov Today 12 650–656 (2007)
n Discusses the use of hollow nanoparticles
6 Boczkowski J Lanone S Potential uses of carbon nanotubes in the medical field how worried should patients be Nanomedicine (Lond) 2(4) 407–410 (2007)
7 Son SJ Bai X Nan A Ghandehari H Lee SB Template synthesis of multifunctional nanotubes for controlled release J Control Release 114 143–152 (2006)
8 He B Kim SK Son SJ Lee SB Shapecoded silica nanotubes for multiplexed bioassay rapid and reliable magnetic decoding protocols Nanomedicine (Lond) 5(1) 77–88 (2010)
9 Oberdster G Oberdster E Oberdster J Nanotoxicoloty An emerging discipline evolving from studies of ultrafine particles Environ Health Perspect 113 823–839 (2005)
n Discusses the nanotoxicological disciplin on ultrafine particles
10 Faunce TA White J Matthaei KI Integrated research into the nanoparticle–protein corona a new focus for safe sustainable and equitable development of nanomedicines Nanomedicine 3(6) 859–866 (2008)
11 Singh N Nanotoxicology health and environmental impacts Nanomedicine (Lond) 4(4) 385–390 (2009)
12 Park MV Lankveld DP van Loveren H de Jong WH The status of in vitro toxicity studies in the risk assessment of nanomaterials Nanomedicine (Lond) 4(6) 669–685 (2009)
13 Faunce T Watal A Nanosilver and global public health international regulatory issues Nanomedicine (Lond) 5(4) 617–632 (2010)
14 Donaldson K Murphy F Schinwald A Duffin R Poland CA Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safetybydesign Nanomedicine (Lond) 6(1) 143–156 (2011)
15 Almeida JPM Chen AL Foster A Drezek R In vivo biodistribution of nanoparticles Nanomedicine (Lond) 6(5) 815–835 (2011)
16 Hirsch C Roesslein M Krug HF Wick PNanomaterialcellinteractions are current in vitro testsreliable Nanomedicine (Lond) 6(5) 837–847 (2011)
17 Kong B Seog JH Graham LM Lee SB Experimental considerations on the cytotoxicity of nanoparticles Nanomedicine (Lond) 6(5) 929–941 (2011)
18 Nerl HC Cheng C Goode AE et al Imaging methods for determining uptake and toxicity of carbon nanotubes in vitro and in vivo Nanomedicine (Lond) 6(5) 849–865 (2011)
19 Fubini B Fenoglio I Tomatis M Turci F Effect of chemical composition and state of the surface on the toxic response to high aspect ratio nanomaterials Nanomedicine (Lond) 6(5) 899–920 (2011)
20 Choi SJ Choy JH Layered double hydroxide nanoparticles as targetspecific delivery carriers uptake mechanism and toxicity 6(5) 803–814 (2011)
21 Zhang LW Bumer W MonteiroRiviere NA Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells Nanomedicine (Lond) 6(5) 777–791 (2011)
22 GarciaBennett AE Synthesis toxicology and potential of ordered mesoporous materials in nanomedicine Nanomedicine (Lond) 6(5) 867–877 (2011)
23 Stensberg MC Wei Q McLamore E Porterfield DM Wei A Sepúlveda MS Toxicological studies on silver nanoparticles challenges and opportunities in assessment monitoring and imaging Nanomedicine (Lond) 6(5) 879–898 (2011)
24 Chou LYT Chan WCW A strategy to assemble nanoparticles with polymers for mitigating cytotoxicity and enabling size tuning Nanomedicine (Lond) 6(5) 767–775 (2011)
25 Hong S Kim KY Wook HJ et al Attenuation of the in vivo toxicity of biomaterials by polydopamine surface modification Nanomedicine (Lond) 6(5) 793–801 (2011)
26 Graham LM Nguyen TM Lee SB Nanodetoxification emerging role of nanomaterials in drug intoxication treatment Nanomedicine (Lond) 6(5) 921–928
撤消修改
(2011)
撤消修改
撤消修改
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关键建立新毒理学研究偏离修改传统方法
新兴意义设计高性纳米材料继续研究未更程度利广泛生物医学越越关注出现寻常意想毒性需性更高反应寻常复杂形状障碍细胞造材料具纳米级[114]建立新毒理学研究偏离修改常规方法必少
纳米粒子影响难评估生物学素细胞吸收体行排泄种素控制改变组成形态路线剂量显着影响免疫反应毒副作外预见细胞毒性毒性试验干扰控制足属性影响特定结果
方面纳米特殊焦点问题提供机会阅读讨显著纳米毒理学研究工作方面新方法生物模型实验关注Drezek事目前已提供广泛审查纳米生物分布毒性状态研究[15]作者讨长期体研究必性充分调查毒性免疫反应排泄纳米粒子需时间体外实验中走系统化方法纳米粒子间改进相关属性观察影响解决新兴纳米技术安全标准库克事审查讨
目前体外毒性分析检测性重问题性组建议系列控件
提高实验质量增加纳米技术安全持续利未[16]外李事强调重纳米粒子细胞毒性实验影响素改进实验注意事项需解决问题获数更界定利影响纳米粒子[17]波特事审查讨表征碳纳米毒性互补纳米测量需理化性质毒性[18]作者建议组合高分辨率电子显微镜解技术细胞活力检测网站定位毒性机制稳定细胞碳纳米组织关纳米材料具体类Fubini定讨类纳米粒子高宽重点相关特性导致毒性作[19]作者指出形式组合相似处足建立毒性规模效应形式耐久性组成表面改性必须追究高长宽纳米粒子蔡财提供概述细胞摄取机制行层状双金属氢氧化物毒性体外体注重效果理化性质剂量互动生物相容性生物系统
[20]张BAUMER研究文章中蒙泰罗里维耶尔探讨毒性细胞树突状细胞量子点吸收脱落细胞赖新光源摄取细胞类型细胞分化途径[21]加西亚·贝特出概述序介孔纳米材料应集中高表面积孔体积装载释放力等纳米粒子行[22]stensberg事提供激烈讨
研究运输活动细胞纳米银生命生物体水传统方式结合成立纳米粒子方法表征[23]作者提出基样研究机制调查新银纳米粒子吸收运动建立更模型评估长期体影响研究集中改善生物相容性新型纳米粒子毒性限制提出问题陈周讨战略疏水纳米粒子双亲聚合物限度减少毒性增强纳米粒子稳定性聚合物保护壳[24]李某事谈成功评价生物相容性聚巴胺专注血液中免疫原性组织炎症反应[25]该组发现聚巴胺提供生物相容性纳米涂层材料表面会否表现出定程度毒性 leeand事提供透视纳米粒子作解毒方法物种通身体讨作台二氧化硅纳米化学氧化活性降低毒化合物[做研究[26]
鉴越越关注两新纳米功材料发展健康环境问题关系材料领域研究员负责完整理解纳米材料理化性质开发新标准建立新标准领域识需长时间（10年）然寻求新纳米医学技术会造成延迟
参考书目
特说明文件已强调
撤消修改
1 Amin RM Mohamed MB Ramadan MA Verwanger T Krammer B Rapid and sensitive microplate assay for screening the effect of silver and gold nanoparticles on bacteria Nanomedicin(Lond) 4(6) 637–643 (2009)
n Nanoparticlebased sensing technology
2 Muthu MS Wilson B Multifunctional radionanomedicine a novel nanoplatform for cancer imaging and therapy Nanomedicine (Lond) 5(2) 169–171 (2010)
n Enhanced imaging technology by nanomaterials
3 Bai X Son SJ Zhang SX et al Synthesis of superparamagnetic nanotubes as MRI contrast agents and for cell labeling Nanomedicine (Lond) 3(2) 163–174 (2008)
4 Nie S Understanding and overcoming major barriers in cancer nanomedicine Nanomedicine (Lond) 5(4) 523–528 (2010)
n Discusses technical barriers of cancer nanotechnology
5 Son SJ Bai X Lee SB Inorganic hollow nanoparticles and nanotubes in nanomedicine part 1 Druggene delivery applications Drug Discov Today 12 650–656 (2007)
n Discusses the use of hollow nanoparticles
6 Boczkowski J Lanone S Potential uses of carbon nanotubes in the medical field how worried should patients be Nanomedicine (Lond) 2(4) 407–410 (2007)
7 Son SJ Bai X Nan A Ghandehari H Lee SB Template synthesis of multifunctional nanotubes for controlled release J Control Release 114 143–152 (2006)
8 He B Kim SK Son SJ Lee SB Shapecoded silica nanotubes for multiplexed bioassay rapid and reliable magnetic decoding protocols Nanomedicine (Lond) 5(1) 77–88 (2010)
9 Oberdster G Oberdster E Oberdster J Nanotoxicoloty An emerging discipline evolving from studies of ultrafine particles Environ Health Perspect 113 823–839 (2005)
n Discusses the nanotoxicological disciplin on ultrafine particles
10 Faunce TA White J Matthaei KI Integrated research into the nanoparticle–protein corona a new focus for safe sustainable and equitable development of nanomedicines Nanomedicine 3(6) 859–866 (2008)
11 Singh N Nanotoxicology health and environmental impacts Nanomedicine (Lond) 4(4) 385–390 (2009)
12 Park MV Lankveld DP van Loveren H de Jong WH The status of in vitro toxicity studies in the risk assessment of nanomaterials Nanomedicine (Lond) 4(6) 669–685 (2009)
13 Faunce T Watal A Nanosilver and global public health international regulatory issues Nanomedicine (Lond) 5(4) 617–632 (2010)
14 Donaldson K Murphy F Schinwald A Duffin R Poland CA Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safetybydesign Nanomedicine (Lond) 6(1) 143–156 (2011)
15 Almeida JPM Chen AL Foster A Drezek R In vivo biodistribution of nanoparticles Nanomedicine (Lond) 6(5) 815–835 (2011)
16 Hirsch C Roesslein M Krug HF Wick PNanomaterialcellinteractions are current in vitro testsreliable Nanomedicine (Lond) 6(5) 837–847 (2011)
17 Kong B Seog JH Graham LM Lee SB Experimental considerations on the cytotoxicity of nanoparticles Nanomedicine (Lond) 6(5) 929–941 (2011)
18 Nerl HC Cheng C Goode AE et al Imaging methods for determining uptake and toxicity of carbon nanotubes in vitro and in vivo Nanomedicine (Lond) 6(5) 849–865 (2011)
19 Fubini B Fenoglio I Tomatis M Turci F Effect of chemical composition and state of the surface on the toxic response to high aspect ratio nanomaterials Nanomedicine (Lond) 6(5) 899–920 (2011)
20 Choi SJ Choy JH Layered double hydroxide nanoparticles as targetspecific delivery carriers uptake mechanism and toxicity 6(5) 803–814 (2011)
21 Zhang LW Bumer W MonteiroRiviere NA Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells Nanomedicine (Lond) 6(5) 777–791 (2011)
22 GarciaBennett AE Synthesis toxicology and potential of ordered mesoporous materials in nanomedicine Nanomedicine (Lond) 6(5) 867–877 (2011)
23 Stensberg MC Wei Q McLamore E Porterfield DM Wei A Sepúlveda MS Toxicological studies on silver nanoparticles challenges and opportunities in assessment monitoring and imaging Nanomedicine (Lond) 6(5) 879–898 (2011)
24 Chou LYT Chan WCW A strategy to assemble nanoparticles with polymers for mitigating cytotoxicity and enabling size tuning Nanomedicine (Lond) 6(5) 767–775 (2011)
25 Hong S Kim KY Wook HJ et al Attenuation of the in vivo toxicity of biomaterials by polydopamine surface modification Nanomedicine (Lond) 6(5) 793–801 (2011)
26 Graham LM Nguyen TM Lee SB Nanodetoxification emerging role of nanomaterials in drug intoxication treatment Nanomedicine (Lond) 6(5) 921–928
撤消修改
(2011)
撤消修改
撤消修改
文香网httpwwwxiangdangnet
《香当网》用户分享的内容，不代表《香当网》观点或立场，请自行判断内容的真实性和可靠性！
该内容是文档的文本内容，更好的格式请下载文档